Comparing Juul puffs to traditional cigarettes can help provide perspective on nicotine intake. How many Juul puffs equal a cigarette? It is challenging to determine an exact equivalency due to variations in nicotine levels and individual smoking habits. However, some estimates suggest that around 10 puffs from a Juul pod may contain nicotine equivalent to that of a single cigarette. It is important to note that individual experiences may vary.